Arun G Ingale
North Maharashtra University, India
Title: DENV3 envelope protein of dengue virus: A potential target for the vaccine designing
Biography
Biography: Arun G Ingale
Abstract
Dengue is arthropod-borne viral disease mainly found in Southeast Asia, the Pacific and the Americas. There are four antigenically discrete serotypes of dengue viruses (DENV1-4) each of which is competent of causing dengue fever, hemorrhagic fever and dengue shock syndrome and currently circulating in these areas. An estimated 50 million dengue infection cases occur globally with around 500,000 cases of hemorrhagic dengue and 20,000 deaths per year. In India, numbers of dengue fever cases are increasing every year. Currently, vaccines and antiviral drugs are under investigation could also make vital contribution to dengue control in the future. Hence, there is dire aspiration to develop new vaccine or drugs that are more targeted fewer lethal and more successful against this virus. Here we analyzed structural components of DENV3 envelope protein for development of homology model and prediction of their antigenic determinants. This work may contribute to effectively target and cultivate operational epitope vaccine to defend the host from the virus.