Perez Bawoh
St. Francis Higher Institute of Nursing and Midwifery Junior/Laboratory Technician Holy Trinity Hospital, Cameroon
Title: Anti-plasmodial Agents from a Cameroonian medicinal plant
Biography
Biography: Perez Bawoh
Abstract
This work, entitled “Anti-plasmodial Agents from a Cameroonian Medicinal Plant”, reports the isolation, structure determination and pharmacological evaluation of constituents isolated from Peperomia vulcanica (Piperaceae). This plant was chosen because it is added to anti-fever preparations by traditional medical practitioners. Repeated column chromatography of the plant extracts afforded thirteen compounds, eight compounds from the hexane extract and five from the methylene chloride extract, three of which have been completely identified as shown compounds. Phytochemical investigation of the crude hexane and methylene chloride extracts resulted in the isolation of thirteen compounds, seven were active, one of which, 5 Demethyltangeretin, was tested for vi Vitro activity against plasmodium falciparium for the first time. Others were identified as stimasterol and matairesirol dimethyether. The structures of the compounds were determined by modern spectroscopic techniques (1H-NMR, 13C-NMR) and physical characteristics as well by comparism of their spectroscopic data with literature values. In vitro activity assessment against plasmodium falciparium was performed using microtittre plates.