Ling Zhan
University of California, USA
Title: Mutans Streptococci Genomic Sequencing: Potential applications for precision medicine to prevent tooth decay
Biography
Biography: Ling Zhan
Abstract
Tooth decay is the most prevalent chronic infectious disease in children. Mutans streptococci (MS) is one of the major families of cariogenic bacteria. MS virulence is critical in determining its ability to cause tooth decay. We hypothesize that the virulence factors of MS are genetically determined. Therefore, we conducted a study to identify potential virulence genes in MS by comparing full-genome sequences of mutans streptococci isolates from caries-free children versus children with severe early childhood caries. This study has identified several novel biosynthetic gene clusters that may play a significant role in regulating MS colonization and competition in oral biofilm and their cariogenicity. We are further studying the function of these genes and gene products. These findings can provide a scientific basis for developing genetic identification tools for caries risk-assessment and targeted caries prevention as a part of precision medicine.
