Aditya
University of Illinois at Chicago, USA
Title: Procalcitonin Levels in Intensive Care Unit setting in patients with positive blood cultures
Biography
Biography: Aditya
Abstract
Background: Procalcitonin (PCT) is a biomarker of severe sepsis caused by bacterial infections. There is a paucity of evidence about the relationship of procalcitonin levels with variables such as site of infection and comorbidities. Methods: We conducted a retrospective pilot study of patients admitted to the medical and cardiac intensive care unit (ICU) from December 1, 2013 to November 30, 2014. Adults over 18 years of age with 1 positive blood culture and PCT levels drawn within 24 hours were included. 48 patients met these criteria. PCT levels were compared between true positive and contaminant/false positive blood cultures. Contaminated cultures were defined as coagulase negative Staphylococcus and diphtheroids with other non-infectious sources of sepsis. Site of infection was defined as respiratory, line-related, skin or soft tissue, intra-abdominal, or urinary tract. Co-morbidities investigated were systolic and diastolic heart failure, acute and chronic renal failure. Independent sample t tests and Pearson’s correlations were used for analysis using SPSS®22. Results: Mean PCT levels were higher in intra-abdominal (19.54±22.14) compared to respiratory infections (3.55±7.64), p=0.067. PCT levels were higher in patients with kidney dysfunction, (r=0.541, p<0.001). Higher mortality was observed in patients with positive blood cultures, 58% compared to average ICU mortality rates of 30-35%. There were no statistically significant differences between mean PCT levels for true versus false positive blood cultures (53.63±130.52 versus 24.21±61.34, p=0.61), congestive heart failure, age, and race.