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Quesada-Gomez C


Quesada-Gomez C

Universidad de Costa Rica, Costa Rica

Biography

Carlos Quesada-Gómez is a lecturer on Anaerobic Bacteriology, School of Microbiology, University of Costa Rica. He has a M.Sc. in Medical Bacteriology and is currently a Ph.D. Candidate working with Clostridium difficile. His research group is working on the molecular characterization of different isolates by PFGE, toxinotyping, MLST and whole genome sequence methods which have made possible the description of the hipervirulent NAP1/027 and other novel genotypes in Costa Rica and Latin America. C. difficile pathogenesis is another area of study in which the level of virulence is being associated with the genotypes and its toxins using cellular and animal models

Abstract

Abstract : Recombination in the substrate recognition domain of TcdB confers a variant glucosyl transferase activity and a distinctive cytopathic effect to a Clostridium difficile strain from the hypervirulent clade II